000 02581cam a2200289Ii 4500
003 GSU
005 20240710173648.0
006
008 181101t20192019enka ob 001 0 eng d
020 _a9780128139578 (paperback)
040 _beng
_cGSU
_erda
050 4 _aRM301.25
_bKEN
100 1 _aKenakin, Terry P.,
_eauthor.
_0http://id.loc.gov/authorities/names/n86105077.
245 1 2 _aA pharmacology primer :
_btechniques for more effective and strategic drug discovery /
_cTerry P. Kenakin, PhD, Professor, Department of Pharmacology, University of North Carolina School of Medicine, United States.
250 _aFifth edition.
260 _aLondon, United Kingdom ;
_bElsevier,
_c2019
264 4 _c©2019.
300 _axiii, 473 pages
_billustrations (some color)
_c27 cm
336 _atext
_btxt
_2rdacontent.
337 _aunmediated
_bn
_2rdamedia.
338 _avolume
_bnc
_2rdacarrier.
504 _aIncludes bibliographical references and index.
505 0 _aWhat is pharmacology? -- How different tissues process drug response -- Drug-receptor theory -- Pharmacological assay formats : binding -- Agonists : the measurement of affinity and efficacy in functional assays -- Orthosteric drug antagonism -- Allosteric modulation -- The optimal design of pharmacological experiments -- Pharmacokinetics -- Safety pharmacology -- The drug discovery process -- Statistics and experimental design -- Selected pharmacological methods -- Exercises in pharmacodynamics and pharmacokinetics.
520 _aA Pharmacology Primer: Techniques for More Effective and Strategic Drug Discovery, Fifth Edition features the latest ideas and research regarding the application of pharmacology to the process of drug discovery. Written by well-respected pharmacologist, Terry P. Kenakin, this primer is an indispensable resource for all those involved in drug discovery. This updated edition has been thoroughly revised to include material on quantifying drug efficacy through bias and cluster analysis, the impact of molecular dynamics and protein structural analysis, the real time kinetic analysis of drug effect, virtual screening for new drug chemical scaffolds, and much more. With full color illustrations and new examples throughout, this book remains a top reference for all industry and academic scientists that is also ideal for students directly involved in drug discovery or pharmacologic research.
650 0 _aPharmacology, Experimental.
_0http://id.loc.gov/authorities/subjects/sh85100600.
942 _2lcc
_cBK
_eFifth edition
_hRM301.25
_iKEN
_kRM
_mKEN
_n0
999 _c2194
_d2194