000 | 02581cam a2200289Ii 4500 | ||
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003 | GSU | ||
005 | 20240710173648.0 | ||
006 | |||
008 | 181101t20192019enka ob 001 0 eng d | ||
020 | _a9780128139578 (paperback) | ||
040 |
_beng _cGSU _erda |
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050 | 4 |
_aRM301.25 _bKEN |
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100 | 1 |
_aKenakin, Terry P., _eauthor. _0http://id.loc.gov/authorities/names/n86105077. |
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245 | 1 | 2 |
_aA pharmacology primer : _btechniques for more effective and strategic drug discovery / _cTerry P. Kenakin, PhD, Professor, Department of Pharmacology, University of North Carolina School of Medicine, United States. |
250 | _aFifth edition. | ||
260 |
_aLondon, United Kingdom ; _bElsevier, _c2019 |
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264 | 4 | _c©2019. | |
300 |
_axiii, 473 pages _billustrations (some color) _c27 cm |
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336 |
_atext _btxt _2rdacontent. |
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337 |
_aunmediated _bn _2rdamedia. |
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338 |
_avolume _bnc _2rdacarrier. |
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504 | _aIncludes bibliographical references and index. | ||
505 | 0 | _aWhat is pharmacology? -- How different tissues process drug response -- Drug-receptor theory -- Pharmacological assay formats : binding -- Agonists : the measurement of affinity and efficacy in functional assays -- Orthosteric drug antagonism -- Allosteric modulation -- The optimal design of pharmacological experiments -- Pharmacokinetics -- Safety pharmacology -- The drug discovery process -- Statistics and experimental design -- Selected pharmacological methods -- Exercises in pharmacodynamics and pharmacokinetics. | |
520 | _aA Pharmacology Primer: Techniques for More Effective and Strategic Drug Discovery, Fifth Edition features the latest ideas and research regarding the application of pharmacology to the process of drug discovery. Written by well-respected pharmacologist, Terry P. Kenakin, this primer is an indispensable resource for all those involved in drug discovery. This updated edition has been thoroughly revised to include material on quantifying drug efficacy through bias and cluster analysis, the impact of molecular dynamics and protein structural analysis, the real time kinetic analysis of drug effect, virtual screening for new drug chemical scaffolds, and much more. With full color illustrations and new examples throughout, this book remains a top reference for all industry and academic scientists that is also ideal for students directly involved in drug discovery or pharmacologic research. | ||
650 | 0 |
_aPharmacology, Experimental. _0http://id.loc.gov/authorities/subjects/sh85100600. |
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942 |
_2lcc _cBK _eFifth edition _hRM301.25 _iKEN _kRM _mKEN _n0 |
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999 |
_c2194 _d2194 |