000 | 03351cam a22004457i 4500 | ||
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001 | 22138772 | ||
003 | OSt | ||
005 | 20221115100253.0 | ||
008 | 210716t20182018ne a 001 0 eng d | ||
010 | _a 2020302873 | ||
015 |
_aGBB8B2117 _2bnb |
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016 | 7 |
_a018914718 _2Uk |
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020 | _a008102083X | ||
020 | _a9780081020838 | ||
020 | _z9780081021057 (ePub ebook) | ||
035 | _a(OCoLC)on1004360838 | ||
040 |
_aYDX _beng _cYDX _erda _dGSU _dOCLCF _dUKMGB _dDLC _dGSU |
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042 | _alccopycat | ||
050 | 0 | 0 |
_aRS403 _bSIL |
082 | 0 | 4 |
_a615.7 _223 |
100 | 1 |
_aSilakari, Om, _eeditor. |
|
245 | 0 | 0 |
_aKey heterocycle cores for designing multitargeting molecules / _cedited by Om Silakari, Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, Punjab, India. |
264 | 1 |
_aAmsterdam : _bElsevier, _c[2018] |
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264 | 4 | _c©2018 | |
300 |
_axiv, 422 pages : _billustrations (some color) ; _c23 cm |
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336 |
_atext _btxt _2rdacontent |
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337 |
_aunmediated _bn _2rdamedia |
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338 |
_avolume _bnc _2rdacarrier |
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504 | _aIncludes bibliographical references and index. | ||
505 | 0 | _aMultitargeting heterocycles: improved and rational chemical probes for multifactorial diseases -- Benzimidazole: journey from single targeting to multitargeting molecule -- Acridones: a relatively lesser explored heterocycle for multifactorial diseases -- Flavone: an important scaffold for medicinal chemistry -- Thiazolidine-2,4-dione: a potential weapon for targeting multiple pathological conditions -- Oxindole: a nucleus enriched with multitargeting potential against complex disorders -- Thiazine: a versatile heterocyclic sccaffold for multifactorial diseases -- Indoles: As multitarget directed ligands in medicinal chemistry -- Triazoles: multidimensional 5-membered nucleus for designing multitargeting agents -- Benzoxazolinone: A scaffold with diverse pharmacological significance. | |
520 | _aKey Heterocycle Cores for Designing Multitargeting Molecules provides a helpful overview of current developments in the field. Following a detailed introduction to the manipulation of heterocycle cores for the development of dual or multitargeting molecules, the book goes on to describe specific examples of such developments, focusing on compounds such as Benzimidazole, Acridine, Flavones, Thiazolidinedione and Oxazoline. Drawing on the latest developments in the field, this volume provides a valuable guide to current approaches in the design and development of molecules capable of acting on multiple targets. Adapting the heterocyclic core of a single-target molecule can facilitate its development into an agent capable of acting on multiple targets. Such multi-targeting drugs have the potential to become essential components in the design of novel, holistic treatment plans for complex diseases, making the design of such active agents an increasingly important area of research. | ||
650 | 0 | _aPharmaceutical chemistry. | |
650 | 0 | _aHeterocyclic compounds. | |
650 | 7 |
_aHeterocyclic compounds. _2fast _0(OCoLC)fst00955736 |
|
650 | 7 |
_aPharmaceutical chemistry. _2fast _0(OCoLC)fst01060115 |
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776 | 0 | 8 |
_iebook version : _z9780081021057 |
906 |
_a7 _bcbc _ccopycat _d2 _encip _f20 _gy-gencatlg |
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942 |
_2lcc _cBK _n0 |
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999 |
_c1392 _d1392 |