Bio-instructive scaffolds for musculoskeletal tissue engineering and regenerative medicine / edited by Justin L. Brown, The Pennsylvania State University, University Park, PA, United Sates, Sangamesh G. Kumbar, UConn Health, Farmington, CT, United States, University of Connecticut, Storrs, CT, United States, Brittany L. Banik, The Pennsylvania State University, University Park, PA, United Sates.

Includes bibliographical references and index.

Bio-Instructive Cues in Scaffolds for Musculoskeletal Tissue Engineering and Regenerative Medicine / K.L. Collins [and three others] -- Functionalizing With Bioactive Peptides to Generate Bio-Instructive Scaffolds / S. Mahzoon, T.J. Siahaan, M.S. Detamore -- Bio-Instructive Scaffolds for Bone Regeneration / F. Han [and three others] -- Bio-Instructive Scaffolds for Tendon/Ligament Regeneration / P.S. Thayer, A.S. Goldstein -- Bio-Instructive Scaffolds for Cartilage Regeneration / N. Mistry [and five others] -- Ultrastructure and Biomechanics of Skeletal Muscle ECM: Implications in Tissue Regeneration / B. Brazile [and seven others] -- Bio-Instructive Scaffolds for Muscle Regeneration: NonCrosslinked Polymers / L. Altomare, S. Farè, M. Cristina Tanzi -- Bio-Instructive Scaffolds for Skeletal Muscle Regeneration: Conductive Materials / J.W. Freeman, D.P. Browe -- Bio-Instructive Scaffolds for Musculoskeletal Interfaces / B.L. Banik [and three others].

"Bio-Instructive Scaffolds for Musculoskeletal Tissue Engineering and Regenerative Medicine explores musculoskeletal tissue growth and development across populations, ranging from elite athletes to the elderly. The regeneration and reparation of musculoskeletal tissues present the unique challenges of requiring both the need to withstand distinct forces applied to the body and ability to support cell populations. The book is separated into sections based on tissue type, including bone, cartilage, ligament and tendon, muscle, and musculoskeletal tissue interfaces. Within each tissue type, the chapters are subcategorized into strategies focused on cells, hydrogels, polymers, and other materials (i.e. ceramics and metals) utilized in musculoskeletal tissue engineering applications. In each chapter, the relationships that exist amongst the strategy, stem cell differentiation and somatic cell specialization at the intracellular level are emphasized. Examples include intracellular signaling through growth factor delivery, geometry sensing of the surrounding network, and cell signaling that stems from altered population dynamics"-- Publisher's website.